Overexpression of RCC2 enhances cell motility and promotes tumor metastasis in lung adenocarcinoma by inducing epithelial–mesenchymal transition

B Pang, N Wu, R Guan, L Pang, X Li, S Li, L Tang… - Clinical Cancer …, 2017 - AACR
Purpose: Investigate the role of regulator of chromosome condensation 2 (RCC2) on lung
adenocarcinoma (LUAD) metastasis. Experimental Design: Clinical specimens were used to …

CCR1 knockdown suppresses human non-small cell lung cancer cell invasion

CL Wang, BS Sun, Y Tang, HQ Zhuang… - Journal of cancer research …, 2009 - Springer
Purpose CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of
leukocytes to the site of inflammation. Tumor invasion and metastasis share many …

CCL2 promotes metastasis and epithelial–mesenchymal transition of non‐small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways

H Xu, J Wang, M Al‐Nusaif, H Ma, W Le - Cell Proliferation, 2024 - Wiley Online Library
In non‐small cell lung cancer (NSCLC), metastasis is the most common phenotype, and
autophagy plays a vital role in its regulation. However, there are limited data on how …

[HTML][HTML] Comprehensive analysis of the expression profile and clinical implications of regulator of chromosome condensation 2 in pan-cancers

X Li, K Kang, Y Peng, L Shen, L Shen, Y Zhou - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Abstract The Regulator of Chromosome Condensation 2 (RCC2) is an important gene that
regulates mitosis and cytoplasmic division in the cell cycle. Although there have been …

[HTML][HTML] Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells

J An, Y Xue, M Long, G Zhang, J Zhang, H Su - Oncotarget, 2017 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, which is the
leading cancer killer in the world. Despite the recent advances in its diagnosis and therapy …

RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells

J Wu, Z He, XM Yang, KL Li, DL Wang, FL Sun - Cancer letters, 2017 - Elsevier
Lung cancer is one of the most lethal cancers due to its highly metastatic spreading. The
motility of lung cancer cells is regulated by paracrine factors, such as TGF-β, in the tumor …

[HTML][HTML] CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner

Y Niu, D Tang, L Fan, W Gao… - Experimental and …, 2020 - spandidos-publications.com
The CC chemokine receptor 9 (CCR9) and its natural secreted ligand CC motif chemokine
ligand 25 (CCL25) have been implicated in cancer metastasis. However, their metastatic …

[HTML][HTML] Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma

XP Zhang, ZJ Hu, AH Meng, GC Duan… - Oncology …, 2017 - spandidos-publications.com
Previous studies have revealed that carcinoma‑associated fibroblasts communicate
microenvironment-derived signals through chemokine/chemokine receptor interaction …

[HTML][HTML] CCR7 promote lymph node metastasis via regulating VEGF-C/D-R3 pathway in lung adenocarcinoma

J Yu, S Tao, P Hu, R Wang, C Fang, Y Xu, D Qi… - Journal of …, 2017 - ncbi.nlm.nih.gov
Lymph node metastasis is still an important issue in metastatic process of lung
adenocarcinoma. CC chemokine receptor 7 (CCR7) has been proved to be closely …

CCL5 increases lung cancer migration via PI3K, Akt and NF-κB pathways

CY Huang, YC Fong, CY Lee, MY Chen, HC Tsai… - Biochemical …, 2009 - Elsevier
CCL5 (previously called RANTES) is in the CC-chemokine family and plays a crucial role in
the migration and metastasis of human cancer cells. Besides, integrins are the major …