Intraplantar formalin injection produces early (Phase 1, 0-to 5-minute) and late (Phase 2, 15-
plus minutes after injection) nociceptive responses, including painlike behavior and …

Injection of dilute formalin into the hindpaw produces brief (phase 1) and persistent (phase
2) nociceptive responses in the rat. We recently reported that ongoing peripheral nerve input …

Hindpaw injection of dilute formalin produces brief (Phase 1) and persistent (Phase 2)
nociceptive responses in the rat. We recently showed that systemically-administered …

To determine whether a lumbar spinal mechanism mediates the late phase of the
nociceptive response in the formalin test, we compared the effects of intrathecal (it) lidocaine …

The effects of local treatment with opioid receptor agonists on the early (0–10 min) and late
(20–40 min) behavioural response and extravasation induced by intraplantar injection of 1 …

Formalin (0.25, 0.5, 3, and 5%) injected into the knee joint of rats induced a dose-dependent
nociception that was featured by 2 phases of intense guarding behavior of the affected limb …

Previous work has demonstrated that pain facilitation can occur following injection of
subcutaneous irritants, such as formalin. Such studies have focused on apparent pain …

The orofacial formalin test in the rat is a valid and reliable model of nociception and is
sensitive to various classes of analgesic drugs. The noxious stimulus consists in an injection …

The purpose of this study was to investigate whether 1%, 2% or 5% formalin injection
produce hypersensitivity with characteristics of the neuropathic pain induced by spinal nerve …

Methods To test our hypothesis, in the first set of experiments, we evaluated nociceptive
response after two consecutive injection of formalin (50µL, 2%), with intervals of 5 or 60 …