There is growing preclinical evidence for the involvement of glutamate in the behavioral
actions of nicotine. The aim of this study, was to investigate the role of N-methyl-D-aspartate …

Rationale Our previous study using memantine in smokers suggests that there may be a
differential role for N-methyl-d-aspartate (NMDA) receptors in the subjective and cognitive …

Introduction: Increasing evidence indicates a crucial role of glutamate in the brain reward
system and nicotine addiction. Because the pertinent models involve frontal and …

Preclinical research findings in laboratory animals indicate that the glutamatergic system is
critically involved in nicotine dependence. In animals, compounds that decrease …

Rationale Findings from animal studies and human PET imaging indicate that nicotine and
cigarette smoking affect glutamate (Glu) and related neurochemical markers in the brain and …

Distinct lines of evidence indicate that glutamate plays a primary role in modulating cognitive
functions. Notably, competitive glutamate receptor antagonists acting at ionotropic N-methyl …

Nicotine plays an important role in the initiation and maintenance of tobacco smoking.
Importantly, chronic nicotine exposure alters the function of brain reward systems, resulting …

Nicotine, a nicotinic acetylcholine receptor agonist, produces the reinforcing effects of
tobacco dependence by potentiating dopaminergic and glutamatergic neurotransmission …

Nicotine dependence is the primary motivational factor perpetuating the tobacco smoking
habit that is one of the leading preventable causes of morbidity throughout the world. This …

Nicotine is a psychoactive ingredient in tobacco that significantly contributes to the harmful
tobacco smoking habit. Nicotine dependence is more prevalent than dependence on any …