Pathogenicity and virulence are multifactorial traits, depending on interaction of viruses with
susceptible cells and organisms. The ion channels coded by viruses, viroporins, represent …

One of the features of cytolytic viral infection of cells is an increase in plasma membrane
permeability. The loss of cellular metabolites and osmotic effects eventually lead to rupture …

Ion channels are membrane proteins that are found in a number of viruses and which are of
crucial physiological importance in the viral life cycle. They have one common feature in that …

Viral ion channels are short membrane proteins with 50–120 amino acids and play an
important role either in regulating virus replication, such as virus entry, assembly and …

The recent special issue of FEBS Letters devoted to Viral Ion Channels (552/1, 18
September 2003) described a number of viral proteins that are thought to have an important …

Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable
pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only …

Viral ion channels are short auxiliary membrane proteins with a length of ca. 100 amino
acids. They are found in enveloped viruses from influenza A, influenza B and influenza C …

In 1996, three viral proteins, NB of influenza B virus prior to molecular cloning of the cDNA
and the expression of the ion channel in heterologous systems. Thus, and Vpu and Vpr of …

Influenza A virus AM2 protein is an integral membrane protein that is an ion channel (also
known as a viroporin). The channel has 24 extracellular residues, 19 residues that span the …

Since the discovery that certain small viral membrane proteins, collectively termed as
viroporins, can permeabilize host cellular membranes and also behave as ion channels …