Our goal was to identify the role of poly (ADP-ribose) polymerase (PARP) in cerebrovascular
dysfunction in Type 1 diabetes mellitus (T1D). In a first series of studies, rats were assigned …

The study has been undertaken to evaluate the effect of streptozotocin (STZ)-induced
diabetes on rat brain poly (ADP-ribose) polymerase (Parp) activity and assess whether and …

Objective: The goal was to identify the role of NAD (P) H oxidase in cerebrovascular
dysfunction in type 1 diabetes mellitus (T1D). Methods: In a first series of studies, rats were …

Background and Purpose—Although the incidence of type II diabetes is increasing, very little
is known regarding vascular responses in the cerebral circulation in this disease. The goals …

Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy,
but the mechanisms remain unidentified. Here we provide evidence that poly (ADP-ribose) …

Oxygen-and nitrogen-derived free radicals and oxidants play an important role in the
pathogenesis of diabetic endothelial dysfunction. Recently we proposed the importance of …

Background and Purpose—During diabetes, expression of inducible nitric oxide synthase
(iNOS) plays an important role in the development of endothelial dysfunction in extracranial …

Abstract Aims/hypothesis. Poly (ADP-ribose) polymerase activation depletes NAD+ and high-
energy phosphates, activates protein kinase C, and affects gene expression in various …

In diabetes, activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) is an
important effector of oxidative-nitrosative injury, which contributes to the development of …

Patients with diabetes exhibit a high incidence of diabetic cardiomyopathy and vascular
complications, which underlie the development of retinopathy, nephropathy, and neuropathy …