Infertility, defined as the inability to conceive after 1 year of unprotected intercourse, affects 1
in 10 couples in the United States (Chandra and Stephen 1998). The etiologies of infertility …

The genetic control of mammalian gametogenesis is inadequately characterized because of
a lack of mutations causing infertility. To further the discovery of genes required for …

The study of reproductive genetics in mammals has lagged behind that of simpler and more
tractable model organisms, such as D. melanogaster, C. elegans and various yeast models …

Early in embryogenesis, cells that are destined to become germ cells take on a different
destiny from other cells in the embryo. The germ cells are not programmed to perform “vital” …

Spermatogenesis is a complex process that involves stem-cell renewal, genome
reorganization and genome repackaging, and that culminates in the production of motile …

Infertility, defined as the inability to conceive after 1year of unprotected intercourse, is a
healthcare problem that has a worldwide impact. Male factors are involved in at least half of …

To accommodate diverse personal needs in family planning, diverse contraceptive
approaches are desirable. This goal requires identification of new contraceptive targets …

Infertility affects an estimated 10% of couples, and in roughly half of these cases the defect
can be traced to the man. Several groups have expressed the concern that male-infertility …

Our understanding of reproduction and early embryonic development has directly enabled
our manipulation of the mouse genome for tests of gene function in vivo. In this review, we …

The review has four objectives. The first objective is to summarize our studies of gene
mutations that induce infertility in male mice. The second objective is to stress the power of …