Recent evidence demonstrates that peripheral immune cells contribute to the nociceptive
hypersensitivity associated with neuropathic pain by infiltrating the central nervous system …

A catastrophic consequence of peripheral nerve injury is the development of abnormal,
chronic neuropathic pain. The inflammatory response at the injury site is believed to …

The analgesic effects of leukocyte-derived opioids have been exclusively demonstrated for
somatic inflammatory pain, for example, the pain associated with surgery and arthritis …

The present study was undertaken to determine whether leukocytes are recruited into the
spinal cord following a peripheral L5 spinal nerve transection that results in mechanical …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Neuropathic pain is a debilitating consequence of nerve injuries and is frequently resistant
to classical therapies. T lymphocytes mediate adaptive immune responses and have been …

Partial sciatic nerve injury is a common model of neuropathic pain in rodents, and produces
both mechanical and thermal pain hypersensitivity. Several types of immune cells have …

Peripheral nerve damage involves inflammation, and is frequently causal to the
development of neuropathic pain. However, inflammatory neuropathies often occur in the …

In inflammatory neuropathy, immune activation near intact peripheral nerves induces
mechanical allodynia. The identity of the peripheral immune product (s) that lead to these …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …