Hepatitis C virus (HCV) cannot be grown in vitro, making biochemical identification of new
drug targets especially important. HCV p7 is a small hydrophobic protein of unknown …

We previously identified the function of the hepatitis C virus (HCV) p7 protein as an ion
channel in artificial lipid bilayers and demonstrated that this in vitro activity is inhibited by …

The p7 protein of hepatitis C virus functions as an ion channel both in vitro and in cell-based
assays and is inhibited by amantadine, long alkyl chain imino-sugar derivatives, and …

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid
membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives …

The hepatitis C virus (HCV) p7 protein plays a critical role during particle formation in cell
culture and is required for virus replication in chimpanzees. The discovery that it displayed …

The hepatitis C virus (HCV) p7 protein forms an amantadine-sensitive ion channel required
for viral replication in chimpanzees, though its precise role in the life cycle of HCV is …

The role of the hepatitis C virus (HCV) p7 protein in the virus life cycle is not known. Previous
in vitro data indicated that this 63-aa polypeptide is located in the endoplasmic reticulum …

Chemotherapy for patients chronically infected with hepatitis C virus (HCV) is ineffective in
over 50% of cases, generating a high demand for new drug targets. The p7 protein of HCV …

The small membrane protein p7 of hepatitis C virus forms oligomers and exhibits ion
channel activity essential for virus infectivity. These viroporin features render p7 an attractive …

Hepatitis C virus (HCV) p7 is a membrane-associated oligomeric protein harboring ion
channel activity. It is essential for effective assembly and release of infectious HCV particles …