The aim of this study was to identify novel antimelanogenic drugs from an epigenetic
screening library containing various modulators targeting DNA methyltransferases, histone …

Down‐regulation of melanin synthesis is required for recovery of pigmentary disorders and it
is known that direct inhibitors of tyrosinase, the key enzyme in melanin synthesis, such as …

Human melanin is synthesized in melanosomes located in melanocytes of the skin, hair,
eyes, ears, and leptomeninges. Melanin not only determines skin color, but also protects the …

5, 6, 7, 8-Tetrahydro-4H-cyclohepta [d] isoxazole derivatives were synthesized and
evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) …

Melanin protects the skin against ultraviolet (UV) rays. It is produced in excess by UV
radiation, which causes skin disorders and pigmentation. Retinoic acid (RA) decreases the …

Here we examined the effects of a DNA methylation inhibitor, 5-azacytidine, on
melanogenesis in Mel-Ab cells. We found that 5-azacytidine decreased the melanin content …

Melanoma, which most often results from genome instability and malignant growth of
melanocytes, is a worldwide epidemic. As reported by the World Health Organization …

Abstract We synthesized (Z)-5-(2, 4-dihydroxybenzylidene) thiazolidine-2, 4-dione
(MHY498) as a potential tyrosinase inhibitor. MHY498 potently inhibited mushroom …

Currently, there are three major assaying methods used to validate in vitro whitening activity
from natural products: methods using mushroom tyrosinase, human tyrosinase, and …

Although melanin production is a key self-defense mechanism against ultraviolet radiation
(UVR)-induced skin damage, uneven or excessive deposition of melanin causes …