A quantitative analytical method to discriminate among the various types of cancerous
esophagus tissue is essential for accurate cancer staging. This paper reports on the use of …

Intrinsic two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG)
signals are shown to differentiate between normal and neoplastic human esophageal …

Liver fibrosis is associated with an abnormal increase in an extracellular matrix in chronic
liver diseases. Quantitative characterization of fibrillar collagen in intact tissue is essential for …

Murine induced colon cancer has been used to demonstrate that Second Harmonic
Generation (SHG) microscopy images, combined with Two-Photon Excitation Fluorescence …

Non-linear optical (NLO) imaging based on two-photon excitation (2PE) and second
harmonic generation (SHG) has been widely used to image microstructures of biomedical …

During precancer development in epithelium, neoplastic cells remodel the underlying
stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular …

In this paper, microstructures of human oesophageal submucosa are evaluated using
multiphoton microscopy, based on two‐photon excited fluorescence and second harmonic …

Changes in the ultrastructure of collagen in various tumor and non-tumor human tissues
including lung, pancreas and thyroid were investigated ex vivo by a polarization-sensitive …

Thin tissue sections of normal and tumorous pancreatic tissues stained with hematoxylin
and eosin were investigated using multiphoton excitation fluorescence (MPF), second …

The continuing development of nonlinear optical imaging techniques has opened many new
windows in biological exploration. In this study, a nonlinear optical microscopy-multiphoton …