Small studies suggest that amiodarone is a weak inhibitor of cytochrome P450 (CYP) 2D6.
Inhibition of CYP2D6 leads to increases in concentrations of drugs metabolized by the …

Amiodarone has pharmacokinetic interactions with a number of therapeutic drugs, including
warfarin, phenytoin, flecainide, and cyclosporine. Metoprolol is mainly metabolized by …

Background Amiodarone (AM) is the most effective antiarrhythmic drug and its major
metabolite desethylamiodarone (DEA) is pharmacologically effective as well. A β 1 blocker …

Effect of amiodarone on the plasma levels of metoprolol - ScienceDirect Skip to main contentSkip
to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download full …

Background: Metoprolol, a beta-blocker, is used to reduce the heart rate. Although it has
been demonstrated that the metoprolol plasma concentration is higher in women than in …

Aims To predict the drug interactions of amiodarone and other drugs, the inhibitory effects
and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and …

Amiodarone alters the pharmacokinetics, and in some cases the pharmacodynamics, of
several clinically important drugs. The major mechanism of its drug interactions is inhibition …

Objectives To estimate and compare the risk of emergent bradycardia associated with
starting immediate‐release (IR) and slow‐release (SR) formulations of metoprolol. Design …

In this study, IC50 shift and time-dependent inhibition (TDI) experiments were carried out to
measure the ability of amiodarone (AMIO), and its circulating human metabolites, to …

After administration of metoprolol, plasma concentrations of the drug are markedly higher in
CYP2D6 poor metabolizers (PMs) than in non‐PMs. In a prospective double‐blind 3‐month …