[HTML][HTML] Protective effects of calorie restriction and 17-β estradiol on cardiac hypertrophy in ovariectomized obese rats

Z Hajializadeh, M Khaksari, S Dabiri… - Plos one, 2023 - journals.plos.org
Obesity and menopause lead to cardiovascular diseases. Calorie restriction (CR) can
modulate estrogen deficiency and obesity-related cardiovascular diseases. The protective …

Substitution of calorie restriction for protective effects of estrogen on cardiometabolic risk factors and oxidative stress in obese postmenopausal rat model

Z Hajializadeh, M Khaksari, H Najafipour, M Sanjari… - Life Sciences, 2022 - Elsevier
Estrogen has an anti-obesity effect and plays an important role in improving cardiometabolic
disorders. Weight loss and reduction in calorie intake impede the development of obesity …

Cardioprotective effects of severe calorie restriction from birth in adult ovariectomized rats

CM Rodrigues, TE Domingues, C de Sousa Santos… - Life Sciences, 2021 - Elsevier
Aims Menopause is a female condition induced by a reduction of ovarian hormone and is
related to an increase in cardiovascular diseases in women. We have shown that severe …

[HTML][HTML] Effects of the loss of estrogen on the heart's hypertrophic response to chronic left ventricle volume overload in rats

E Walsh-Wilkinson, C Beaumont, MC Drolet, ÈM Roy… - PeerJ, 2019 - peerj.com
Aortic valve regurgitation (AR) can result in heart failure from chronic overloading of the left
ventricle (LV). Little is known of the role of estrogens in the LV responses to this condition …

Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats

S Sivasinprasasn, P Sa-Nguanmoo, W Pratchayasakul… - Age, 2015 - Springer
Women have a lower incidence of cardiovascular diseases (CVD) than men at a similar age
but have an increased incidence of CVD and metabolic syndrome after menopause …

Cardioprotective effects of calorie restriction against inflammation and apoptosis in ovariectomized obese rats: Role of classical estrogen receptors and SIRT1

Z Hajializadeh, M Khaksari - Obesity Research & Clinical Practice, 2023 - Elsevier
Aim Obesity is a metabolic complication linked with bad eating habits and a sedentary
lifestyle, and the heart is one of the target organs damaged by it. Estrogen deficiency during …

Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet

J Buniam, N Chukijrungroat… - American Journal …, 2019 - journals.physiology.org
The prevalence of cardiometabolic syndrome (CMS) is increased in women after
menopause. While hormone replacement therapy has been prescribed to relieve several …

[HTML][HTML] Treatment with 17β-estradiol reduced body weight and the risk of cardiovascular disease in a high-fat diet-induced animal model of obesity

WJ Ting, CY Huang, CH Jiang, YM Lin… - International journal of …, 2017 - mdpi.com
Estrogen receptor α (ERα) and estrogen receptor β (ERβ) play important roles in
cardiovascular disease (CVD) prevention. Recently, these estrogen receptors were …

17β-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats

S Zafirovic, M Obradovic, E Sudar-Milovanovic… - Molecular and Cellular …, 2017 - Elsevier
The aim of this study was to investigate the in vivo effects of 17β-estradiol (E 2) on
myocardial metabolism and inducible nitric oxide synthase (iNOS) expression/activity in …

Effects of Estrogen on Cardiovascular Injury in Ovariectomized Female DahlS.Z-Leprfa/Leprfa Rats as a New Animal Model of Metabolic Syndrome

T Murase, T Hattori, M Ohtake, C Nakashima… - …, 2012 - Am Heart Assoc
Although recent clinical trials have found an increased incidence of cardiovascular disease
in women on estrogen replacement therapy, the underlying mechanism remains unclear …