Cognitive impairment and “invisible symptoms” are not associated with CCSVI in MS

C Leone, E D'Amico, S Cilia, A Nicoletti, L Di Pino… - BMC neurology, 2013 - Springer
Background We investigated the association between chronic cerebrospinal venous
insufficiency (CCSVI) and cognitive impairment (CI) in multiple sclerosis (MS). Moreover, we …

Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis

RHB Benedict, B Weinstock-Guttmam, K Marr… - BMC medicine, 2013 - Springer
Background Chronic cerebrospinal venous insufficiency (CCSVI) has been reported in
multiple sclerosis (MS) yet its significance in relation to cognitive function is undetermined …

Multiple sclerosis and CCSVI: a population-based case control study

F Patti, A Nicoletti, C Leone, S Messina, E D'Amico… - 2012 - journals.plos.org
Background Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to
multiple sclerosis (MS). Objective To evaluate the possible association between CCSVI and …

Survival, cognitive functions, and brain MRI in patients with cSVD: 5-year observation

LA Dobrynina, ZS Gadzhieva… - Annals of clinical …, 2022 - annaly-nevrologii.com
Introduction. Contributing to high disability and mortality, cerebral small vessel disease
(cSVD) is a common condition in senior and elderly individuals. Objective: to assess the 5 …

Funding CCSVI research is/was a waste of valuable time, money and intellectual energy: no

R Zivadinov… - Multiple Sclerosis Journal, 2013 - journals.sagepub.com
Zivadinov and Weinstock-Guttman 859 of healthy controls and patients with other neurologic
diseases. 13 The binary variable construction of the CCSVI diagnosis (yes/no) is probably …

Chronic cerebrospinal venous insufficiency is not associated with multiple sclerosis and its severity: a blind-verified study

MA Leone, O Raymkulova, P Naldi, P Lochner… - PLoS …, 2013 - journals.plos.org
Background Chronic Cerebrospinal Venous Insufficiency (CCSVI) has been associated with
multiple sclerosis (MS) with a risk ranging from as high as two-hundred-fold to a protective …

Italian multicentre observational study of the prevalence of CCSVI in multiple sclerosis (CoSMo study): rationale, design, and methodology

G Comi, MA Battaglia, A Bertolotto, M Del Sette… - Neurological …, 2013 - Springer
Chronic cerebro-spinal venous insufficiency (CCSVI) has been proposed as a “congenital
malformation” implicated in the pathogenesis of multiple sclerosis (MS). However, numerous …

Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis

B Weinstock-Guttman, M Ramanathan, K Marr… - BMC neurology, 2012 - Springer
Background Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition
characterized by anomalies of the primary veins outside the skull that has been reported to …

Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study

S Bastianello, A Romani, G Viselner, EC Tibaldi… - BMC neurology, 2011 - Springer
Background Chronic cerebrospinal venous insufficiency (CCSVI) has recently been reported
to be associated with multiple sclerosis (MS). However, its actual prevalence, possible …

Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study

G Comi, MA Battaglia, A Bertolotto… - Multiple Sclerosis …, 2013 - journals.sagepub.com
Background: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a
possible cause of multiple sclerosis (MS). Objectives: The CoSMo study evaluated the …