Clostridium sordellii lethal toxin (LT) is a glucosyltransferase which inactivates small
GTPases from the Rho and Ras families. In the present work, we studied the effects of two …

Inactivation of different small GTPases upon their glucosylation by lethal toxin from
Clostridium sordellii strain IP82 (LT‐82) is already known to lead to cell rounding, adherens …

The lethal toxin (LT) from Clostridium sordellii belongs to the family of large clostridial
cytotoxins causing morphological alterations in cultured cell lines accompanied by …

When intraperitoneally injected into Swiss mice, Clostridium sordellii lethal toxin reproduces
the fatal toxic shock syndrome observed in humans and animals after natural infection. This …

Clostridium sordellii infections cause gangrene and edema in humans and gastrointestinal
infections in livestock. One of the principle virulence factors is TcsL, a large protein toxin …

Lethal toxin (LT) from Clostridium sordellii is one of the high molecular mass clostridial
cytotoxins. On cultured cells, it causes a rounding of cell bodies and a disruption of actin …

Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe
toxic shock in man and animals. TcsL belongs to the large clostridial glucosylating toxin …

Clostridium sordellii lethal toxin (TcsL) is a large clostridial toxin (LCT) that glucosylates Ras,
Rac, and Ral. TcsL differs from other LCTs because it modifies Ras, which does not cycle …

Large clostridial glucosylating toxins (LCGTs) are produced by toxigenic strains of C
lostridium difficile, C lostridium perfringens, C lostridium novyi and C lostridium sordellii …

The large clostridial cytotoxins (LCTs) constitute a group of high molecular weight clostridial
cytotoxins that inactivate cellular small GTP-binding proteins. We demonstrate that a novel …