Mammalian cells respond to their substrates by complex changes in gene expression
profiles, morphology, proliferation and migration. We report that substrate nanotopography …

Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …

Manipulating neural stem cell (NSC) fate is of great importance for improving the therapeutic
efficacy of NSCs to treat neurodegenerative disorders. Biophysical cues, in addition to …

The maintenance of stem cell pluripotency or stemness is crucial to embryonic development
and differentiation. The mechanical or physical microenvironment of stem cells, which …

Recently emerging evidence has indicated surface nanotopography as an important
physical parameter in the stem cell niche for regulating cell fate and behaviors for various …

Regulated biophysical cues, such as nanotopography, have been shown to be integral for
tissue regeneration and embryogenesis in the stem cell niche. Tissue homeostasis involves …

Understanding of stem cell–surface interactions and, in particular, long-term maintenance of
stem cell pluripotency on well-defined synthetic surfaces is crucial for fundamental research …

Embryonic stem cells (ESC) are pluripotent cells capable to give rise to any embryonic cell
lineage. In culture, these cells form colonies creating their own niche. Depending upon the …

Contact guidance has been extensively explored using patterned adhesion functionalities
that predominantly mimic cell–matrix interactions. Whether contact guidance can also be …

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of
stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with …