The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis
JH Rand, XX Wu, AS Quinn, DJ Taatjes - Lupus, 2010 - journals.sagepub.com
Annexin A5 (AnxA5) binds to phospholipid bilayers, forming two-dimensional crystals that
block the phospholipids from availability for coagulation enzyme reactions. Antiphospholipid …
block the phospholipids from availability for coagulation enzyme reactions. Antiphospholipid …
Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial …
Abstract Annexin A5 (AnxA5) is a potent anticoagulant protein that crystallizes over
phospholipid bilayers (PLBs), blocking their availability for coagulation reactions …
phospholipid bilayers (PLBs), blocking their availability for coagulation reactions …
Resistance to annexin A5 anticoagulant activity: a thrombogenic mechanism for the antiphospholipid syndrome
JH Rand, XX Wu, AS Quinn, DJ Taatjes - Lupus, 2008 - journals.sagepub.com
The phospholipid binding protein, annexin A5 (AnxA5), has potent anticoagulant properties
that result from its forming 2-dimensional crystals over phospholipids, blocking the …
that result from its forming 2-dimensional crystals over phospholipids, blocking the …
Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy …
JH Rand, XX Wu, AS Quinn, PP Chen… - The American journal of …, 2003 - Elsevier
The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …
Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
JH Rand, XX Wu, R Lapinski, WL van Heerde… - Blood, 2004 - ashpublications.org
Abstract Annexin A5 (A5) forms 2-dimensional crystals over phospholipid bilayers, blocking
their availability for coagulation reactions. Recently, human antiphospholipid (aPL) …
their availability for coagulation reactions. Recently, human antiphospholipid (aPL) …
Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression
XX Wu, S Guller, JH Rand - American journal of obstetrics and gynecology, 2011 - Elsevier
OBJECTIVE: Antibody-mediated disruption of the annexin A5 anticoagulant shield has been
posited to be a thrombogenic mechanism in the antiphospholipid syndrome. We recently …
posited to be a thrombogenic mechanism in the antiphospholipid syndrome. We recently …
Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss
H Ueki, T Mizushina, T Laoharatchatathanin… - Scientific Reports, 2012 - nature.com
Antiphospholipid syndrome is associated with an increased risk of thrombosis and
pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however …
pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however …
Annexin A5 polymorphism (− 1C→ T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome
B de Laat, RHWM Derksen, IJ Mackie… - Annals of the …, 2006 - ard.bmj.com
Background: Annexin A5 is thought to have a role in the pathophysiology of the
antiphospholipid syndrome (APS)—a syndrome characterised by recurrent thrombosis and …
antiphospholipid syndrome (APS)—a syndrome characterised by recurrent thrombosis and …
Antibody-mediated disruption of the annexin-V antithrombotic shield: a new mechanism for thrombosis in the antiphospholipid syndrome
JH Rand, XX Wu - Thrombosis and haemostasis, 1999 - thieme-connect.com
The antiphospholipid (aPL) syndrome is a condition that manifests in patients as vascular
thromboembolism or recurrent pregnancy loss together with laboratory evidence for the …
thromboembolism or recurrent pregnancy loss together with laboratory evidence for the …
Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome
G Cesarman-Maus, NP Ríos-Luna, AB Deora, B Huang… - Blood, 2006 - ashpublications.org
The association of thrombosis and gestational morbidity with antiphospholipid antibodies is
termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell …
termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell …