Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

Recent studies have established a strong link between copper and cancer biology, as
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …

Highlights•Overview of copper complexes as potent anticancer chemotherapeutic
agents.•Copper complexes are endogenously biocompatible and exhibit reduced side …

Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure
sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production …

As one of the most important essential transition metals, copper is involved in a variety of
biological processes such as embryo development, connective tissue formation …

Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

Copper (Cu) is an essential micronutrient involved in a variety of fundamental biological
processes. Recently, disorder of Cu homeostasis can be observed in many malignancies …

Copper is an essential transition metal frequently increased in cancer known to strongly
influence essential cellular processes. Targeted therapy protocols utilizing both novel and …

Background Copper was reported to be involved in the onset and progression of cancer.
Proteins in charge of copper uptake and distribution, as well as cuproenzymes, are altered …