NH125 Sensitizes Staphylococcus aureus to Cell Wall-Targeting Antibiotics through the Inhibition of the VraS Sensor Histidine Kinase
S Bhattarai, L Marsh, K Knight, L Ali… - Microbiology …, 2023 - Am Soc Microbiol
Staphylococcus aureus utilizes the two-component regulatory system VraSR to receive and
relay environmental stress signals, and it is implicated in the development of bacterial …
relay environmental stress signals, and it is implicated in the development of bacterial …
The dimerization interface in VraR is essential for induction of the cell wall stress response in Staphylococcus aureus: a potential druggable target
G Tajbakhsh, D Golemi-Kotra - BMC microbiology, 2019 - Springer
Background Staphylococcus aureus remains a medical challenge in the treatment of
bacterial infections. It has acquired resistance to commonly used antibiotics, and to those …
bacterial infections. It has acquired resistance to commonly used antibiotics, and to those …
A close-up view of the VraSR two-component system: a mediator of Staphylococcus aureus response to cell wall damage
A Belcheva, D Golemi-Kotra - Journal of biological chemistry, 2008 - ASBMB
Staphylococcus aureus remains a clinical scourge. Recent studies have revealed that S.
aureus is capable of mounting a response to antibiotics that target cell wall peptidoglycan …
aureus is capable of mounting a response to antibiotics that target cell wall peptidoglycan …
Site-Specific Mutation of Staphylococcus aureus VraS Reveals a Crucial Role for the VraR-VraS Sensor in the Emergence of Glycopeptide Resistance
E Galbusera, A Renzoni, DO Andrey… - Antimicrobial agents …, 2011 - Am Soc Microbiol
An initial response of Staphylococcus aureus to encounter with cell wall-active antibiotics
occurs by transmembrane signaling systems that orchestrate changes in gene expression to …
occurs by transmembrane signaling systems that orchestrate changes in gene expression to …
Role of VraSR in Antibiotic Resistance and Antibiotic-Induced Stress Response in Staphylococcus aureus
Exposure of Staphylococcus aureus to cell wall inhibitors induces massive overexpression
of a number of genes, provided that the VraSR two-component sensory regulatory system is …
of a number of genes, provided that the VraSR two-component sensory regulatory system is …
Revisiting the Role of VraTSR in Staphylococcus aureus Response to Cell Wall-Targeting Antibiotics
PB Fernandes, P Reed, JM Monteiro… - Journal of …, 2022 - Am Soc Microbiol
Exposure of Staphylococcus aureus to cell wall inhibitors leads to the activation of the
VraTSR three-component sensory regulatory system. This system is composed of VraS, a …
VraTSR three-component sensory regulatory system. This system is composed of VraS, a …
Chromatin immunoprecipitation identifies genes under direct VraSR regulation in Staphylococcus aureus
Transcriptional profiling of Staphylococcus aureus treated with cell wall-active antibiotics
identified the 2-component system, VraSR, as one of the key players in response to …
identified the 2-component system, VraSR, as one of the key players in response to …
A novel mode of regulation of the Staphylococcus aureus Vancomycin-resistance-associated response regulator VraR mediated by Stk1 protein phosphorylation
MJ Canova, G Baronian, S Brelle… - Biochemical and …, 2014 - Elsevier
Abstract The Staphylococcus aureus Vancomycin-resistance-associated response regulator
VraR is known as an important response regulator, member of the VraTSR three-component …
VraR is known as an important response regulator, member of the VraTSR three-component …
Roles of DNA Sequence and Sigma A Factor in Transcription of the vraSR Operon
A Belcheva, V Verma, A Korenevsky… - Journal of …, 2012 - Am Soc Microbiol
Cell wall damage in Staphylococcus aureus induces a rapid genome-wide response,
referred to as the cell wall stress stimulon. This response is mediated by a two-component …
referred to as the cell wall stress stimulon. This response is mediated by a two-component …
Two‐component system VraSR positively modulates the regulation of cell‐wall biosynthesis pathway in Staphylococcus aureus
M Kuroda, H Kuroda, T Oshima… - Molecular …, 2003 - Wiley Online Library
DNA microarray covering the whole genome of Staphylococcus aureus strain N315 was
prepared to investigate transcription profiles. The microarray analyses revealed that …
prepared to investigate transcription profiles. The microarray analyses revealed that …