Quinone antibiotics, α-and β-rubromycin, were originally found as inhibitors of retroviral
reverse transcriptase. We investigated the effects of these agents on DNA metabolic …

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado
80309-0215 Received March 18, 1991; Revised Manuscript Received June 14, 1991 …

The kinetics of the inhibition of DNA polymerases-α and-β from sea urchin embryos by
pyridoxal 5-phosphate were studied. The inhibition of DNA polymerase-α activity by …

We have purified the DNA polymerase II of Escherichia coli from the recombinant strain
carrying the plasmid which encodes the polB gene. We confirmed that the purified protein, of …

Revised Manuscript Received November 21, 1994® abstract: Toxiusol, a natural product
isolated from the Red Sea sponge Toxiclona toxius, has been shown to be a potent inhibitor …

The agents daunomycin, ethidium bromide, distamycin A and cytochrome c inhibit DNA
dependent DNA polymerase I (E. coli) reaction competitively to DNA. The influence of these …

Abstract BuPdGTP, the 2′-deoxyribonucleoside 5′-triphosphate of the DNA polymerase
alpha (pol α)-specific inhibitor, N 2-(pn-butylphenyl) guanine, was examined with respect to …

Anup K. Hazra, Sevilla Detera-Wadleigh, and SamuelH. Wilson* abstract: Pyridoxal 5'-
phosphate (PLP) is an inhibitor of DNA polymerase activity of Escherichia coli DNA …

Rubromycins, a class of quinone antibacterials, were discovered to selectively inhibit human
immunodeficiency virus-i (HIV-i) RNA-directed DNA polymerase(reverse transcriptase)(AT) …

MATERIALS AND METHODS Chemicals-[Me-3H] Thymidine-5• Œ-triphos phate([3H] dTTP)
and other labeled compounds were purchased from New England Nuclear Co., USA …