The forkhead transcription factor, DAF-16, a downstream target of the insulin/IGF-I signaling
pathway in C. elegans, is indispensable both for lifespan regulation and stress resistance …

In Caenorhabditis elegans, the forkhead protein DAF‐16 transduces insulin‐like signals that
regulate larval development and adult lifespan. To identify DAF‐16‐dependent …

DAF-16/forkhead transcription factor, the downstream target of the insulin-like signaling in
Caenorhabditis elegans, is indispensable for both lifespan regulation and stress resistance …

In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a
robust extension in lifespan, improved late life health, and protection from age-related …

In Caenorhabditis elegans, the insulin/IGF-1 DAF-2 receptor controls entry into dauer and
longevity. DAF-2 signaling cascade includes the PI3 kinase homolog AGE-1 and the FOXO …

Background Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C.
elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of …

The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor
(IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3 …

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced
insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different …

Insulin/IGF‐1 signaling controls metabolism, stress resistance and aging in Caenorhabditis
elegans by regulating the activity of the DAF‐16/FoxO transcription factor (TF). However, the …

Much attention has focused on the insulin-like signaling pathway in Caenorhabditis elegans
because of its pivotal role in life-span determination and oxidative stress resistance. The daf …