The binding of [3H] digoxin to purified canine cardiac sarcolemmal vesicles was
characterized. Scatchard analysis of saturation isotherms yielded linear plots with a maximal …

Recent studies have shown a significant increase in plasma digoxin concentration during
verapamil treatment. This phenomenon has been attributed in part to reduced renal …

To investigate the basis for a clinically important digitalis-quinidine interaction that is
characterized by increases in serums digoxin concentrations when quinidine is …

Methods Bound and unbound digoxin plasma levels were determined in-vitro, in a control
human plasma containing 2.5 x 1CW M (2 ng ml-1) of digoxin to which 1 and 3 pg ml-1 were …

Tissue distribution and left ventricular (LV) effects of digoxin were studied after intravenous
administration of low and high doses to dogs. LV dP/dt was increased by 0.03 mg/kg digoxin …

Digoxin has been associated with a variety of drug interactions. Studies in our laboratory
indicate that single doses of prazosin may alter plasma steady-state digoxin levels. Adult …

Digoxin concentmtions in serum and left ventricular tissue were measured at autopsy and
related to estimated antemortem creatinine clearances in 15 patients. A significant …

The effects of quinidine, quinine, aspirin, ibuprofen, indomethacin and acetaminophen on
steady state serum digoxin concentrations and total body digoxin clearance were studied in …

Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

Serum and myocardial digoxin levels were studied in 18 patients who came to autopsy. An
independent analysis of electrocardiograms prior to death was made to ascertain the …