Objective The leukotrienes are inflammatory mediators. In the present study, the analgesic
role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible …

Background: Various inflammatory mediators are involved in initiating and sustaining
pain/inflammation cascade. Recently, leukotrienes (LTs) have been shown to be important …

This study aimed to investigate the involvement of opioid receptors in the systemic and
peripheral antinociceptive activities of montelukast in different animal models of pain. Rats …

Pain is commonly associated with inflammation. Several mediators including prostaglandins
have been implicated in pain and inflammation. However, the recent reports indicated the …

The leukotrienes are potent inflammatory mediators, which may have a role in inflammatory
diseases such as allergic rhinitis, inflammatory bowl disease and asthma. Zafirlukast, a …

The purpose of this review is to summarize the recent studies examining the expression of
leukotrienes (LTs) and their receptors in nociceptive pathways, and their crucial roles in …

BACKGROUND: Cysteinyl leukotrienes and their receptors have been shown to be involved
in the generation of neuropathic pain. We performed this study to determine the antagonistic …

Background: Leukotrienes (LTs) belong to the large family of lipid mediators implicated in
various inflammatory conditions such as asthma and rheumatoid arthritis. Four distinct types …

AIMS: Ischemia-reperfusion (I/R) event in vascular and nervous system has been
documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the …

Carbamazepine has been shown to exert analgesic effects in clinical and experimental pain
situation. This study was conducted to evaluate its potential peripheral antinociceptive …