Aims/hypothesis Glomerular matrix accumulation is a hallmark of diabetic nephropathy.
Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix …

Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The
serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in …

Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We have recently
shown that epidermal growth factor receptor (EGFR) transactivation mediates high glucose …

High glucose (HG) stimulates glomerular mesangial cell (MC) expression of extracellular
matrix, a process involving protein kinase C (PKC) isozymes and enhanced signaling by …

Increased expression of PDGF receptor-β (PDGFRβ) has been shown in renal proximal
tubules in mice with diabetes. The core molecular network used by high glucose to induce …

Background/Aims: Extracellular matrix accumulation contributes significantly to the
pathogenesis of diabetic nephropathy. Although AMP-activated protein kinase (AMPK) has …

Mesangial matrix expansion is an early lesion leading to glomeruloclerosis and chronic
renal diseases. A beneficial effect is achieved with angiotensin I-converting enzyme …

Glomerular hypertension and glomerular hypertrophy act early and synergistically to
promote glomerular injury in diabetes. We have previously shown that increased renal kinin …

Glomerulosclerosis is one of the complications of diabetes that occurs after many years of
uncontrolled hyperglycemia. Mesangial cells (MCs) exposed to high glucose (HG) for short …

The elevated mRNA levels encoding matrix components in glomeruli isolated from
streptozotocin-induced diabetic rats provide evidence that stimulation of matrix synthesis is …