Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.
M Strathmann, TM Wilkie… - Proceedings of the …, 1990 - National Acad Sciences
The alpha subunit of the guanine nucleotide-binding protein Go (" o" for other) is believed to
mediate signal transduction between a variety of receptors and effectors. cDNA clones …
mediate signal transduction between a variety of receptors and effectors. cDNA clones …
Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.
P Gierschik, G Milligan, M Pines… - Proceedings of the …, 1986 - National Acad Sciences
We immunized rabbits with purified guanine nucleotide-binding proteins (G proteins) from
bovine brain and obtained an antiserum, RV3, that reacts specifically with the alpha subunit …
bovine brain and obtained an antiserum, RV3, that reacts specifically with the alpha subunit …
Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative …
T Tsukamoto, R Toyama, H Itoh… - Proceedings of the …, 1991 - National Acad Sciences
Go is a specific class (" other") of signal-transducing heterotrimeric GTP-binding proteins (G
proteins) that is expressed in high levels in mammalian brain. We have cloned two different …
proteins) that is expressed in high levels in mammalian brain. We have cloned two different …
Antibody specific to the alpha subunit of the guanine nucleotide-binding regulatory protein Go: developmental appearance and immunocytochemical localization in …
KJ Chang, W Pugh, SG Blanchard… - Proceedings of the …, 1988 - National Acad Sciences
A polyclonal rabbit antibody (9120) against the alpha subunit of the" other" guanine
nucleotide-binding protein Go (alpha o) was raised against a synthetic alpha o peptide …
nucleotide-binding protein Go (alpha o) was raised against a synthetic alpha o peptide …
[HTML][HTML] Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein.
WH Hsu, U Rudolph, J Sanford, P Bertrand… - Journal of Biological …, 1990 - Elsevier
We screened a HIT (hamster insulin-secreting tumor) cell cDNA library constructed in
lambda gt11 with a Go-specific oligonucleotide probe and isolated six recombinant phages …
lambda gt11 with a Go-specific oligonucleotide probe and isolated six recombinant phages …
Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus.
BM Denker, CJ Schmidt, EJ Neer - Journal of Biological Chemistry, 1992 - ASBMB
G proteins are active as long as GTP is bound to the alpha subunit. Activation ends when
GTP is cleaved to GDP that then stays bound to the active site. Agonist-liganded receptors …
GTP is cleaved to GDP that then stays bound to the active site. Agonist-liganded receptors …
Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.
PF Worley, JM Baraban, C Van Dop… - Proceedings of the …, 1986 - National Acad Sciences
We have localized a guanine nucleotide-binding protein, Go, in rat brain by
immunohistochemistry with a selective polyclonal antiserum to the alpha 39 subunit of Go …
immunohistochemistry with a selective polyclonal antiserum to the alpha 39 subunit of Go …
[HTML][HTML] Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.
BM Denker, EJ Neer, CJ Schmidt - Journal of Biological Chemistry, 1992 - Elsevier
Heterotrimeric guanine nucleotide-binding proteins are composed of alpha and beta gamma
subunits and couple a variety of cell-surface receptors to intracellular enzymes or ion …
subunits and couple a variety of cell-surface receptors to intracellular enzymes or ion …
Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go
P Goldsmith, PS Backlund Jr, K Rossiter, A Carter… - Biochemistry, 1988 - ACS Publications
Glasgow, Glasgow, Scotland, and Department of Biochemistry, Rockefeller University, New
York, New York 10021 Received February 23, 1988; Revised Manuscript Received May 6 …
York, New York 10021 Received February 23, 1988; Revised Manuscript Received May 6 …
Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.
HK Fong, KK Yoshimoto… - Proceedings of the …, 1988 - National Acad Sciences
Recent molecular cloning of cDNA for the alpha subunit of bovine transducin (a guanine
nucleotide-binding regulatory protein, or G protein) has revealed the presence of two retinal …
nucleotide-binding regulatory protein, or G protein) has revealed the presence of two retinal …