Mammary glands develop postnatally in response to the hypothalamic‐pituitary‐gonadal
axis. Obesity‐induced changes in the local environment, however, retard mammary gland …

Mice lacking leptin (ob/ob) or its full-length receptor (db/db) are obese and reproductively
incompetent. Fertility, pregnancy, and lactation are restored, respectively, in ob/ob mice …

Abstract Development of the functional secretory epithelium in the mammary gland of the
female mouse requires the elongation of the anlage through the mammary fat pad to form …

To investigate the role of adipose tissue in reproductive function and mammary gland
development and function, we have examined lipodystrophic (LD) mice. LD mice of both …

Mammary fat tissue is crucial for mammary ductal morphogenesis in both fetal and adult
mice. There are two kinds of adipocytes, the energy-storing white and the energy-dissipating …

Mammary gland development is critically dependent on the interactions between the stromal
and the epithelial compartments within the gland. These events are under the control of a …

The mouse mammary gland is a complex tissue, which is continually undergoing changes in
structure and function. Embryonically, the gland begins with invasion of the underlying fat …

Alterations to the metabolic environment during puberty can impact future lactation efficiency
and mammary tumorigenesis. During this study, we used a model of rabbits receiving an …

Abstract Development and differentiation of the mammary gland occurs by means of critical
stromal‐epithelial interactions. Although many studies have attempted to understand these …

We have developed a mouse model of diet-induced obesity that shows numerous
abnormalities relating to mammary gland function. Animals ate∼ 40% more calories when …