Ion channels as antivirus targets

X Liang, Z Li - Virologica Sinica, 2010 - Springer
Ion channels are membrane proteins that are found in a number of viruses and which are of
crucial physiological importance in the viral life cycle. They have one common feature in that …

[HTML][HTML] Viral proteins function as ion channels

K Wang, S Xie, B Sun - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Viral ion channels are short membrane proteins with 50–120 amino acids and play an
important role either in regulating virus replication, such as virus entry, assembly and …

Virus Ion Channels Formed by Vpu of HIV-1, the 6K Protein of Alphaviruses and NB of Influenza B Virus

PW Gage, G Ewart, J Melton, A Premkumar - Viral Membrane Proteins …, 2005 - Springer
One of the features of cytolytic viral infection of cells is an increase in plasma membrane
permeability. The loss of cellular metabolites and osmotic effects eventually lead to rupture …

The ion channels coded by viruses

F Čiampor - Acta microbiologica et immunologica hungarica, 2003 - akjournals.com
Pathogenicity and virulence are multifactorial traits, depending on interaction of viruses with
susceptible cells and organisms. The ion channels coded by viruses, viroporins, represent …

[PDF][PDF] Viral ion channels as models for ion transport and targets for antiviral drug action

DLH Pinto - FEBS letters, 2004 - core.ac.uk
The recent special issue of FEBS Letters devoted to Viral Ion Channels (552/1, 18
September 2003) described a number of viral proteins that are thought to have an important …

[HTML][HTML] Viral ion channels: structure and function

WB Fischer, MSP Sansom - Biochimica et Biophysica Acta (BBA) …, 2002 - Elsevier
Viral ion channels are short auxiliary membrane proteins with a length of ca. 100 amino
acids. They are found in enveloped viruses from influenza A, influenza B and influenza C …

[HTML][HTML] Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease

S Gargan, NJ Stevenson - Viruses, 2021 - mdpi.com
The current COVID-19 pandemic has highlighted the need for the research community to
develop a better understanding of viruses, in particular their modes of infection and …

[HTML][HTML] Do Vpu and Vpr of human immunodeficiency virus type 1 and NB of influenza B virus have ion channel activities in the viral life cycles?

RA Lamb, LH Pinto - Virology, 1997 - Elsevier
In 1996, three viral proteins, NB of influenza B virus prior to molecular cloning of the cDNA
and the expression of the ion channel in heterologous systems. Thus, and Vpu and Vpr of …

[HTML][HTML] Ion channels as therapeutic targets for viral infections: further discoveries and future perspectives

FW Charlton, HM Pearson, S Hover, JD Lippiat… - Viruses, 2020 - mdpi.com
Ion channels play key roles in almost all facets of cellular physiology and have emerged as
key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking …

Validation of coronavirus E proteins ion channels as targets for antiviral drugs

L Wilson, P Gage, G Ewart - The Nidoviruses: Toward Control of SARS …, 2006 - Springer
Coronaviruses are divided into three groups, depending on the sequence homology and
antigen cross-reactivity. Groups 1 and 2 contain the mammalian coronaviruses, and group 3 …