The objective of this study was to investigate spinal and supraspinal antinociceptive effects
of a new synthetic compound,(±)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid …

Pain is a major cause of distress, both physical and psychological. There is a continuous
search for new pharmacologically active analgesic agents with minor adverse effects …

In this study, we investigated the role of descending monoaminergic systems in the
antinociceptive activity of FR140423, 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methyl …

Pain is responsible for inducing physical and mental stress, interfering negatively in patients'
quality of life. Classic analgesic drugs, such as opioids and non‐steroidal anti‐inflammatory …

Abstract A novel compound, FR64822 (N-(4-pyridylcarbamoyl) amino 1, 2, 3, 6,-
tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and …

The antinociceptive action of a novel pyrazole-derived compound, 3-methyl-5-hydroxy-5-
trichloromethyl-1H-1-pyrazolcarboxyamide (MPCA) was evaluated using the formalin and …

Abstract The compound (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one [(±)-δ-lactone]
was isolated from the plant Vitex cymosa Bertero, and determined to be the active principle …

The antinociceptive effects produced by intraperitoneal administration of a novel synthetic
chalcone, 3-(2, 3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one (DMFP), were …

Dipyrone injected intraperitoneally (ip) or subplantarly into the mouse paw caused dose-
related antinociception against the early and the late phases of formalin-induced licking …

The antinociceptive effect of dipyrone, a nonsteroidal anti-inflammatory drug, was studied in
a series of experiments employing tail-flick and hot-plate models and the abdominal …