The molecular basis for heart failure is unknown, but oxidative stress is associated with the
pathogenesis of the disease. We tested the hypothesis that the activity of xanthine …

Myocardial dysfunction and heart failure perturb cardio-vascular homeostatic signaling
pathways as well as initiate a program of molecular, biochemical, and structural …

Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …

Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …

The xanthine oxidase pathway has been proposed as a source ofoxygen-derived free
radicals in ischemic and reperfused myocardium. A spectrophotometric assay was …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …

Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Xanthine oxidoreductase (XOR) has been implicated in tissue injury following ischemia-
reperfusion because of its ability to generate reactive oxygen species under these …

The enzyme xanthine oxidase has been implicated as a generator of toxic oxygen
metabolites that contribute to ischemic injury. Because substantial species variability has …