The strategic use of fluorine substitution in drug discovery and drug development is well
documented. The small size and high electronegativity of fluorine are among properties of …

The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

This perspective explores the origins of both fluorine and medicinal chemistry a century ago
and traces the early history of the intersection of these areas and the subsequent roles that …

The small and highly electronegative fluorine atom can play a remarkable role in medicinal
chemistry. Selective installation of fluorine into a therapeutic or diagnostic small molecule …

Fluorine chemistry is an expanding area of research that is attracting international interest,
due to the impact of fluorine in drug discovery and in clinical and molecular imaging (eg …

Fluorine is characterized by high electronegativity and small atomic size, which provide this
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …

The increasing utilization of fluorine in drug design parallels advances in understanding the
physicochemical attributes of this element and an enhanced appreciation of how these …

The applications of fluorinated molecules in bioengineering and nanotechnology are
expanding rapidly with the controlled introduction of fluorine being broadly studied due to …

This reviews details selected fluorine-containing drugs that either have potential for, or are
already in, clinical use. Fluorine imparts desirable characteristics to drugs by modulating …

Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …