ObjectiveSelective serotonin reuptake inhibitors (SSRIs) have been widely used in the
treatment of most anxiety disorders. In this study, to clarify the mechanism of the anxiolytic …

This study investigated the effect of co-administration of the selective 5-HT1A receptor
antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 with a …

The effects of the co-administration of the serotonin (5-HT) 1A receptor antagonists NAN-190
or (+)-WAY100135 with a selective 5-HT reuptake inhibitor (SSRI) citalopram on conditioned …

The purpose of this study was to investigate the effects of co-administration of tandospirone
(a 5-HT1A receptor agonist) and individual selective serotonin reuptake inhibitors (SSRIs) …

Background Though drugs binding to serotonergic 5-HT2A receptors have long been
claimed to influence human anxiety, it remains unclear if this receptor subtype is best …

Our previous study showed that conditioned fear stress (CFS) increased serotonin (5-HT)
metabolism in the medial prefrontal cortex and induced freezing behavior. Although these …

We have recently confirmed that exposure of rats to the single-prolonged stress (SPS)
paradigm induces enhanced hypothalamic–pituitary–adrenal (HPA) axis negative feedback …

An acute challenge with selective serotonin (5-HT) reuptake inhibitors (SSRIs) reduces the
conditioned freezing in rats, a model of anxiety. The increase in the 5-HT levels in the nerve …

Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal
model of anxiety. In the present study, freezing was used to determine the anxiolytic activity …

The purpose of the present study was to elucidate the brain regions in which citalopram, a
selective serotonin reuptake inhibitor (SSRI), exerts its anxiolytic effects in conditioned fear …