The hepatitis C virus (HCV) p7 ion channel plays a critical role during infectious virus
production and represents an important new therapeutic target. Its activity is blocked by …

The hepatitis C virus (HCV) p7 protein plays a critical role during particle formation in cell
culture and is required for virus replication in chimpanzees. The discovery that it displayed …

Hepatitis C virus (HCV) chronically infects 170 million individuals, causing severe liver
disease. Although antiviral chemotherapy exists, the current regimen is ineffective in 50% of …

Hepatitis C is a major worldwide disease and health hazard, affecting∼ 3% of the world
population. The p7 protein of hepatitis C virus (HCV) is an intracellular ion channel and pH …

The novel small molecule, BIT225 (N-[5-(1-methyl-1H-pyrazol-4-yl)-napthalene-2-carbonyl]-
guanidine: CAS No. 917909-71-8), was initially identified using a screening strategy …

Current interferon‐based therapy for hepatitis C virus (HCV) infection is inadequate,
prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease …

Hepatitis C virus (HCV) cannot be grown in vitro, making biochemical identification of new
drug targets especially important. HCV p7 is a small hydrophobic protein of unknown …

Chemotherapy for patients chronically infected with hepatitis C virus (HCV) is ineffective in
over 50% of cases, generating a high demand for new drug targets. The p7 protein of HCV …

Abstract p7, a 63‐residue peptide encoded by hepatitis C virus (HCV), a major pathogen
associated with a risk of developing severe liver disease, is involved in ion channel activity …

Hepatitis C virus (HCV) p7 is a membrane-associated oligomeric protein harboring ion
channel activity. It is essential for effective assembly and release of infectious HCV particles …