Peroxisome proliferator-activated receptor-α is widely distributed in the vasculature where it
is believed to exert pleiotropic antiatherogenic effects. Its role in the regulation of blood …

Nuclear receptors represent a large family of ligand-activated transcription factors which
sense the physiological environment and make long-term adaptations by mediating …

Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated
transcription factors that include PPAR-α, PPAR-γ, and PPAR-δ. We hypothesized that …

Spontaneously hypertensive rats (SHR) develop hypertension (HT) at the age of 2-6 weeks.
Endocardial endothelial (EE) dysfunction, autonomic suppression, left ventricle hypertrophy …

Background Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent
nuclear transcription factors that regulate β-oxidation of fatty acids in various tissues. PPARα …

The anti-inflammatory properties of PPAR-α plays an important role in attenuating
hypertension. The current study determines the anti-hypertensive and anti-inflammatory role …

Background: The aim of the present study was to examine the chronic effects of α-lipoic acid
on proliferator peroxisome activated receptors-γ (PPAR-γ) and PPAR-α expressions in …

Objective—Peroxisome proliferator–activated receptors (PPARs) may modulate in vitro the
vascular production of vasoactive peptides such as endothelin-1 (ET-1). Thus, we …

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor β/δ
(PPARβ) has been shown to improve insulin resistance and plasma high-density lipoprotein …

The complexity of hypertension and atherosclerosis and of the underlying mechanisms is
becoming increasingly apparent. The number of candidate genes and molecular pathways …