Many genotoxic agents kill tumor cells by inducing apoptosis; hence, mutations that
suppress apoptosis produce resistance to chemotherapy. Although directly activating the …

Most of the cytotoxic anticancer drugs in current use have been shown to induce apoptosis
in susceptible cells. The fact that disparate agents, which interact with different targets …

Increasing the susceptibility of tumor cells to apoptotic cell death following chemotherapy is
of importance to the outcome of cancer treatment. Although the tumor suppressor gene p53 …

The cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis.
We report here that tumor cells resistant to CD95 (APO-1/Fas)-mediated apoptosis were …

Oncogenes that promote cell-cycle progression also sensitize cells to agents that induce
apoptosis. Sensitization is thought to be caused by the induction of proapoptotic factors …

The dominant paradigm in cancer treatment is that cancer cells die from the common
pathway of apoptosis subsequent to DNA damage by anticancer agents and that cells …

Although cancer is a disease that will afflict one out of three people in the Western world,
when considered at a cellular level, it is a rare clonal event. Long-lived organisms, such as …

Elimination of transformed fibroblasts through intercellular induction of apoptosis has been
postulated as representing an efficient control step during oncogenesis. Whereas fibroblasts …

Apoptosis is a mode of cell death with characteristic structural features. These appear to
result from a set of discrete cellular events that are regulated by gene expression …

INTRODUCTION: CELL DEATH AS AN ADAPTIVE RESPONSE TO DAMAGE IN TRYING to
understand why many cancer cells do not die after drug treatment, and are drug resistant, it …