Semitelechelic HPMA (N-(2-hydroxypropyl) methacrylamide) copolymers possessing a
single terminal lipophilic triphenylphosphonium (TPP) cation and fluorescent labels were …

Endocytic uptake and subcellular trafficking of a large array of HPMA (N-(2-hydroxypropyl)
methacrylamide) based copolymers possessing positively or negatively charged residues …

Bioactivable nanocarrier systems have favorable characteristics such as high cellular
uptake, target specificity, and an efficient intracellular release mechanism. In this study, we …

Mitochondrial targeting and entry, two crucial steps in fighting severe diseases resulting from
mitochondria dysfunction, pose important challenges in current nanomedicine. Cell …

A wide variety of therapeutic agents may benefit by specifically directing them to the
mitochondria in tumor cells. The current work aimed to design delivery systems that would …

For mitochondria‐targeting delivery, a coupling reaction between poly (ε‐caprolactone) diol
(PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl TPP) results in the …

Mitochondrial-oriented delivery of anticancer drugs has been considered as a promising
strategy to improve the antitumor efficiency of chemotherapeutics. However, the …

The basic physicochemical properties that determine the distribution and fate of synthetic
macromolecules in living cells were characterized using fluorescently labeled HPMA (N-(2 …

Synthetic strategies and chemical and structural aspects of the synthesis of HPMA
copolymer conjugates with various drugs and other biologically active molecules are …

Immediately after administration, polymer therapeutics are exposed to complex biological
media like blood which may influence and alter their physicochemical properties due to …