Objective: To test the hypothesis that oral desogestrel (DSG) plus testosterone would
uniformly and rapidly suppress sperm concentrations in young men as effectively as …

The development of a safe, well‐tolerated, effective, and reversible male hormonal
contraceptive would be a major clinical advance for couples planning their family size and …

Studies using exogenous high‐dosage testosterone (T) or a combination regimen of
physiologic T plus high‐dosage levonorgestrel (LNG) administration in normal men have …

The effects of a synthetic oral progestogen, desogestrel (DSG), administered with low dose
testosterone (T) were investigated to determine the optimal combination for suppression of …

BACKGROUND: Effective hormonal male contraception requires a high prevalence of
spermatogenic suppression, which has proved particularly difficult in Caucasian …

Studies using high dose testosterone (T) administration in normal men as a male
contraceptive have resulted in azoospermia rates of only 50-70%. Previous studies of T and …

The aim of this study was to determine for the first time in humans, the efficacy of adding a
low dose oestradiol to a suboptimally suppressive testosterone dose in a depot hormonal …

Sex-steroid based male contraceptive regimes induce azoospermia in only 40-70% of
Caucasian men. The reason (s) why the remainder maintains a low level of …

Context: Combination of a GnRH antagonist (acyline), types I and II, 5α-reductase inhibitor
(dutasteride) or levonorgestrel (LNG) with testosterone (T) treatment may augment the …

In male contraceptive trials, approximately half of normal men become azoospermic on high
dosages of testosterone enanthate (TE), whereas the other half of men become severely …