Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii
J Mazumdar, E H. Wilson, K Masek… - Proceedings of the …, 2006 - National Acad Sciences
Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …
[HTML][HTML] Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma
X Liang, J Cui, X Yang, N Xia, Y Li, J Zhao… - Journal of Biological …, 2020 - ASBMB
Toxoplasma gondii is a common protozoan parasite that infects a wide range of hosts,
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …
Fatty acid biosynthesis as a drug target in apicomplexan parasites
CD Goodman, GI McFadden - Current drug targets, 2007 - ingentaconnect.com
Apicomplexan parasitic diseases impose devastating impacts on much of the world's
population. The increasing prevalence of drug resistant parasites and the growing number …
population. The increasing prevalence of drug resistant parasites and the growing number …
[HTML][HTML] Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii
S Ramakrishnan, MD Docampo, JI MacRae… - Journal of Biological …, 2012 - ASBMB
Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of
the phylum Apicomplexa. The apicomplexan plastid, or “apicoplast,” is indispensable, but …
the phylum Apicomplexa. The apicomplexan plastid, or “apicoplast,” is indispensable, but …
[HTML][HTML] Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts
The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …
[HTML][HTML] Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal …
S Amiar, JI MacRae, DL Callahan, D Dubois… - PLoS …, 2016 - journals.plos.org
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …
The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell
S Ramakrishnan, MD Docampo… - Molecular …, 2015 - Wiley Online Library
Apicomplexa are parasitic protozoa that cause important human diseases including malaria,
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …
Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors
Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the
apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic …
apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic …
[PDF][PDF] Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling
Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine
lipids from both host cell scavenging and de novo synthesis to maintain parasite …
lipids from both host cell scavenging and de novo synthesis to maintain parasite …