Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii

J Mazumdar, E H. Wilson, K Masek… - Proceedings of the …, 2006 - National Acad Sciences
Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …

[HTML][HTML] Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma

X Liang, J Cui, X Yang, N Xia, Y Li, J Zhao… - Journal of Biological …, 2020 - ASBMB
Toxoplasma gondii is a common protozoan parasite that infects a wide range of hosts,
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …

Fatty acid biosynthesis as a drug target in apicomplexan parasites

CD Goodman, GI McFadden - Current drug targets, 2007 - ingentaconnect.com
Apicomplexan parasitic diseases impose devastating impacts on much of the world's
population. The increasing prevalence of drug resistant parasites and the growing number …

[HTML][HTML] Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii

S Ramakrishnan, MD Docampo, JI MacRae… - Journal of Biological …, 2012 - ASBMB
Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

RF Waller, PJ Keeling, RGK Donald… - Proceedings of the …, 1998 - National Acad Sciences
A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of
the phylum Apicomplexa. The apicomplexan plastid, or “apicoplast,” is indispensable, but …

[HTML][HTML] Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts

MJ Shears, CY Botté, GI McFadden - Molecular and biochemical …, 2015 - Elsevier
The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …

[HTML][HTML] Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal …

S Amiar, JI MacRae, DL Callahan, D Dubois… - PLoS …, 2016 - journals.plos.org
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …

The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell

S Ramakrishnan, MD Docampo… - Molecular …, 2015 - Wiley Online Library
Apicomplexa are parasitic protozoa that cause important human diseases including malaria,
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …

Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors

C Bisanz, O Bastien, D Grando, J Jouhet… - Biochemical …, 2006 - portlandpress.com
Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the
apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic …

[PDF][PDF] Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling

S Amiar, NJ Katris, L Berry, S Dass, S Duley, CS Arnold… - Cell Reports, 2020 - cell.com
Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine
lipids from both host cell scavenging and de novo synthesis to maintain parasite …