Langmuir monolayer techniques for the investigation of model bacterial membranes and antibiotic biodegradation mechanisms

M Rojewska, W Smułek, E Kaczorek, K Prochaska - Membranes, 2021 - mdpi.com
The amounts of antibiotics of anthropogenic origin released and accumulated in the
environment are known to have a negative impact on local communities of microorganisms …

[HTML][HTML] Lipopolysaccharides at solid and liquid interfaces: models for biophysical studies of the gram-negative bacterial outer membrane

N Paracini, E Schneck, A Imberty, S Micciulla - Advances in Colloid and …, 2022 - Elsevier
Lipopolysaccharides (LPSs) are a constitutive element of the cell envelope of Gram-
negative bacteria, representing the main lipid in the external leaflet of their outer membrane …

[HTML][HTML] Molecular organization of bacterial membrane lipids in mixed systems—A comprehensive monolayer study combined with Grazing Incidence X-ray Diffraction …

P Wydro, M Flasiński, M Broniatowski - Biochimica et Biophysica Acta (BBA …, 2012 - Elsevier
To properly design and investigate new antibacterial drugs a detailed description of the
organization of bacterial membrane is highly important. Therefore in this work we performed …

Partitioning of seven different classes of antibiotics into LPS monolayers supports three different permeation mechanisms through the outer bacterial membrane

H Cetuk, A Anishkin, AJ Scott, SB Rempe, RK Ernst… - Langmuir, 2021 - ACS Publications
The outer membrane (OM) of Gram-negative (G−) bacteria presents a barrier for many
classes of antibacterial agents. Lipopolysaccharide (LPS), present in the outer leaflet of the …

[HTML][HTML] Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones

A Khondker, RC Bider, I Passos-Gastaldo… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Numerous antibiotics are known to target intracellular pathways, such as protein translation
or DNA replication. Membrane transporters typically regulate drug uptake; however, little is …

Effect of the phospholipid head group in antibiotic-phospholipid association at water–air interface

F Gambinossi, B Mecheri, M Nocentini, M Puggelli… - Biophysical …, 2004 - Elsevier
We studied the interactions of tetracycline antibiotics, TCs, with phospholipid monolayers
with the two-fold aim of elucidating the mechanism of action of TCs and to provide a first step …

The interactions between phosphatidylglycerol and phosphatidylethanolamines in model bacterial membranes: the effect of the acyl chain length and saturation

P Wydro, K Witkowska - Colloids and Surfaces B: Biointerfaces, 2009 - Elsevier
In this work the Langmuir monolayer technique was applied to study the interactions
between phosphatidylglycerol (PG) and phosphatidylethanolamines (PEs). Since the …

FTIR spectroscopic study of molecular organization of the antibiotic amphotericin B in aqueous solution and in DPPC lipid monolayers containing the sterols …

M Gagoś, M Arczewska - European Biophysics Journal, 2012 - Springer
Langmuir monolayers of amphotericin B (AmB) were investigated by recording π–A
isotherms under different pH conditions. To gain a better insight into antibiotic–membrane …

How does the N-acylation and esterification of amphotericin B molecule affect its interactions with cellular membrane components—the Langmuir monolayer study

K Hąc-Wydro, P Dynarowicz-Łątka… - Colloids and surfaces B …, 2005 - Elsevier
This work presents the results of Langmuir monolayers study of two amphotericin B
derivatives obtained by N-acylation (N-acetylamphotericin B, Ac-AmB) and esterification …

[HTML][HTML] Computer modelling studies of the bilayer/water interface

M Pasenkiewicz-Gierula, K Baczynski… - … et Biophysica Acta (BBA …, 2016 - Elsevier
This review summarises high resolution studies on the interface of lamellar lipid bilayers
composed of the most typical lipid molecules which constitute the lipid matrix of …