Challenges in Identifying New Antimicrobial Agents Effective for Treating Infections with Acinetobacter baumannii and Pseudomonas aeruginosa

LB Rice - Clinical infectious diseases, 2006 - academic.oup.com
Acinetobacter baumannii and Pseudomonas aeruginosa are gram-negative pathogens that
target immunocompromised patients. They express a variety of determinants that confer …

High tigecycline resistance in multidrug-resistant Acinetobacter baumannii

S Navon-Venezia, A Leavitt… - Journal of Antimicrobial …, 2007 - academic.oup.com
Abstract Objectives Multidrug-resistant (MDR) Acinetobacter baumannii is increasing in our
hospital and worldwide, raising the necessity of finding effective therapies. We aimed to …

Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii

AY Peleg, J Adams, DL Paterson - Antimicrobial agents and …, 2007 - Am Soc Microbiol
Tigecycline has an extended spectrum of in vitro antimicrobial activities, including that
against multidrug-resistant Acinetobacter. After identifying bloodstream isolates of …

In Vitro Activity of Tigecycline Against Acinetobacter baumannii: Global Epidemiology and Resistance Mechanisms

S Pournaras, V Koumaki, V Gennimata… - … Infectious Diseases and …, 2016 - Springer
Acinetobacter baumannii is a pathogen of increasing concern, commonly causing outbreaks
in the hospital environment. Of particular concern, A. baumannii strains exhibiting resistance …

Acinetobacter baumannii: Pathogenesis, virulence factors, novel therapeutic options and mechanisms of resistance to antimicrobial agents with emphasis on …

R Dehbanipour, Z Ghalavand - Journal of Clinical Pharmacy …, 2022 - Wiley Online Library
What is known and objective Acinetobacter baumannii is one of the most important
nosocomial pathogens with the ability to cause infections such as meningitis, pneumonia …

[HTML][HTML] Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumannii

SH Ardehali, T Azimi, F Fallah, M Owrang… - New microbes and new …, 2019 - Elsevier
Acinetobacter baumannii is an important human pathogen responsible for a various type of
infections. These bacterial strains are generally resistant to numerous antibiotics. Therefore …

[HTML][HTML] Resistance mechanisms of tigecycline in Acinetobacter baumannii

C Sun, Y Yu, X Hua - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
Acinetobacter baumannii is widely distributed in nature and in hospital settings and is a
common pathogen causing various infectious diseases. Currently, the drug resistance rate …

AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii

M Hornsey, MJ Ellington, M Doumith… - Journal of …, 2010 - academic.oup.com
Objectives Tigecycline non-susceptibility in individual Acinetobacter baumannii isolates has
been associated with up-regulation of the resistance–nodulation–division (RND)-type efflux …

Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii

S Gerson, J Nowak, E Zander, J Ertel… - Journal of …, 2018 - academic.oup.com
Objectives To investigate the mechanisms of tigecycline resistance in isogenic
Acinetobacter baumannii isolate pairs as well as 65 unique clinical A. baumannii isolates …

In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii

L Principe, S D'Arezzo, A Capone, N Petrosillo… - Annals of clinical …, 2009 - Springer
Background Infections sustained by multidrug-resistant (MDR) and pan-resistant
Acinetobacter baumannii have become a challenging problem in Intensive Care Units …