Objectives. Decision models for health technology appraisal are defined by their structure
and data. Often there are alternatives for how the model might be specified and what data to …

Meta-analysis has been well-established for many years, but has been largely confined to
pooling evidence on pair-wise contrasts. Broader forms of synthesis have also been …

Alongside the development of meta-analysis as a tool for summarizing research literature,
there is renewed interest in broader forms of quantitative synthesis that are aimed at …

There is growing interest in using observational data to assess the safety, effectiveness, and
cost effectiveness of medical technologies, but operational, technical, and methodological …

This project comprises a critical exploration and development of methods for the synthesis of
evidence, using a chain of evidence approach, from diverse, yet inter-related, sources. The …

Decision analysis is a systematic, quantitative, and transparent approach to making
decisions under uncertainty. The fundamental tool of decision analysis is a decision-analytic …

Most cost-effectiveness analyses consist of a baseline model that represents the absolute
natural history under a standard treatment in a comparator set and a model for relative …

Background. An increasing number of evidence sources are relevant for populating decision
analytic models. What is needed is detailed methodological advice on which type of data is …

When multiple parameters are estimated from the same synthesis model, it is likely that
correlations will be induced between them. Network meta-analysis (mixed treatment …

Inconsistency can be thought of as a conflict between “direct” evidence on a comparison
between treatments B and C and “indirect” evidence gained from AC and AB trials. Like …