Acute lung injury is an inflammatory condition developed after severe sepsis in response to
excessive secretion of pro-inflammatory cytokines. Doxycycline is widely reported to …

Sepsis is a life-threatening systemic inflammatory condition triggered as a result of an
excessive host immune response to infection. In the past, immunomodulators have …

Antibiotics can have a biological effect apart from their anti-bacterial effect. We hypothesized
that doxycycline could attenuate acute lung injury through its biological effect …

It was demonstrated that doxycycline protected BALB/c mice injected intraperitoneally with
bacterial lipopolysaccharide (LPS) against lethal septic shock. Doxycycline (at 1.5 mg/kg) …

Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening
inflammatory condition predominantly characterized by vascular protein leakage, neutrophil …

Acute lung injury (ALI) is a serious complication of sepsis and an important cause of death in
intensive care. Studies have shown that DEX can inhibit inflammation. However, the anti …

Objective We investigated whether dexmedetomidine provided protective effects on cecal
ligation and puncture (CLP)–induced septic mice, through suppressing the expression of pro …

The influence of ceftiofur on immune responses has been suggested by results of in vitro
studies. This effect was studied using a murine model that measured mortality and early …

Septic shock results from excessive stimulation of host immune cells, particularly monocytes
and macrophages, by lipopolysaccharide (LPS) released from gram-negative bacteria …

Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. High
dose administration (100 or 200 mg/day) is often responsible for development of bacterial …