Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity
in mice. Here we report that GH treatment limited to a few weeks during development …

Mice with genetic growth hormone (GH) deficiency or GH resistance live much longer than
their normal siblings maintained under identical conditions with unlimited access to food …

The exceptional longevity of Ames dwarf (DF) mice can be abrogated by a brief course of
growth hormone (GH) injections started at 2 weeks of age. This transient GH exposure also …

Endocrine mutant mice have proven invaluable toward the quest to uncover mechanisms
underlying longevity. Growth hormone (GH) and insulin-like growth factor (IGF) have been …

In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous
mutations or targeted disruption of GH-or IGF1-related genes can lead to an impressive …

Disruption of the growth hormone (GH) signaling pathway promotes insulin sensitivity and is
associated with both delayed aging and extended longevity. Two kinds of long-lived mice …

Endocrine hormones are thought to be involved in processes that contribute to aging. Long-
living dwarf mice are growth hormone (GH)-deficient and exhibit enhanced expression of …

Reduced growth hormone (GH) action is associated with extended longevity in many
vertebrate species. GH receptor (GHR) null (GHR−/−) mice, which have a disruption in the …

Long-living Ames dwarf mice (df/df) characterized by growth hormone (GH) deficiency are
widely used in aging research because of their 40–60% lifespan extension compared to …

Mutant mice with a combined deficiency of growth hormone (GH), prolactin, and thyrotropin,
and knockout mice with GH resistance, live longer than their normal siblings. The extension …