A large gene family in fission yeast encodes spore killers that subvert Mendel's law
Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their
favor. It remains unclear how many species harbor them and how diverse their mechanisms …
favor. It remains unclear how many species harbor them and how diverse their mechanisms …
On the mechanistic basis of killer meiotic drive in fungi
SJ Saupe, H Johannesson - Annual Review of Microbiology, 2022 - annualreviews.org
Spore killers are specific genetic elements in fungi that kill sexual spores that do not contain
them. A range of studies in the last few years have provided the long-awaited first insights …
them. A range of studies in the last few years have provided the long-awaited first insights …
[HTML][HTML] A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote
Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission
into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve …
into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve …
wtf genes are prolific dual poison-antidote meiotic drivers
NL Nuckolls, MA Bravo Núñez, MT Eickbush… - Elife, 2017 - elifesciences.org
Meiotic drivers are selfish genes that bias their transmission into gametes, defying
Mendelian inheritance. Despite the significant impact of these genomic parasites on …
Mendelian inheritance. Despite the significant impact of these genomic parasites on …
[HTML][HTML] Genes that bias Mendelian segregation
Mendel laws of inheritance can be cheated by Meiotic Drive Elements (MDs), complex
nuclear genetic loci found in various eukaryotic genomes and distorting segregation in their …
nuclear genetic loci found in various eukaryotic genomes and distorting segregation in their …
Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers
MA Bravo Núñez, IM Sabbarini, LE Eide, RL Unckless… - Elife, 2020 - elifesciences.org
Killer meiotic drivers are genetic parasites that destroy 'sibling'gametes lacking the driver
allele. The fitness costs of drive can lead to selection of unlinked suppressors. This …
allele. The fitness costs of drive can lead to selection of unlinked suppressors. This …
The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years
M De Carvalho, GS Jia, AN Srinivasa, RB Billmyre… - Elife, 2022 - elifesciences.org
Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …
Molecular mechanisms and evolutionary consequences of spore killers in ascomycetes
S Zanders, H Johannesson - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
In this review, we examine the fungal spore killers. These are meiotic drive elements that
cheat during sexual reproduction to increase their transmission into the next generation …
cheat during sexual reproduction to increase their transmission into the next generation …
[HTML][HTML] S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive
NL Nuckolls, A Nidamangala Srinivasa, AC Mok… - PLoS …, 2022 - journals.plos.org
Meiotic drivers bias gametogenesis to ensure their transmission into more than half the
offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic drivers destroy the …
offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic drivers destroy the …
The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
Meiotic drivers are parasitic loci that force their own transmission into greater than half of the
offspring of a heterozygote. Many drivers have been identified, but their molecular …
offspring of a heterozygote. Many drivers have been identified, but their molecular …
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