A large gene family in fission yeast encodes spore killers that subvert Mendel's law

W Hu, ZD Jiang, F Suo, JX Zheng, WZ He, LL Du - Elife, 2017 - elifesciences.org
Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their
favor. It remains unclear how many species harbor them and how diverse their mechanisms …

On the mechanistic basis of killer meiotic drive in fungi

SJ Saupe, H Johannesson - Annual Review of Microbiology, 2022 - annualreviews.org
Spore killers are specific genetic elements in fungi that kill sexual spores that do not contain
them. A range of studies in the last few years have provided the long-awaited first insights …

[HTML][HTML] A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote

MA Bravo Núñez, JJ Lange, SE Zanders - PLoS Genetics, 2018 - journals.plos.org
Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission
into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve …

wtf genes are prolific dual poison-antidote meiotic drivers

NL Nuckolls, MA Bravo Núñez, MT Eickbush… - Elife, 2017 - elifesciences.org
Meiotic drivers are selfish genes that bias their transmission into gametes, defying
Mendelian inheritance. Despite the significant impact of these genomic parasites on …

[HTML][HTML] Genes that bias Mendelian segregation

P Grognet, H Lalucque, F Malagnac, P Silar - PLoS genetics, 2014 - journals.plos.org
Mendel laws of inheritance can be cheated by Meiotic Drive Elements (MDs), complex
nuclear genetic loci found in various eukaryotic genomes and distorting segregation in their …

Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers

MA Bravo Núñez, IM Sabbarini, LE Eide, RL Unckless… - Elife, 2020 - elifesciences.org
Killer meiotic drivers are genetic parasites that destroy 'sibling'gametes lacking the driver
allele. The fitness costs of drive can lead to selection of unlinked suppressors. This …

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M De Carvalho, GS Jia, AN Srinivasa, RB Billmyre… - Elife, 2022 - elifesciences.org
Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …

Molecular mechanisms and evolutionary consequences of spore killers in ascomycetes

S Zanders, H Johannesson - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
In this review, we examine the fungal spore killers. These are meiotic drive elements that
cheat during sexual reproduction to increase their transmission into the next generation …

[HTML][HTML] S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive

NL Nuckolls, A Nidamangala Srinivasa, AC Mok… - PLoS …, 2022 - journals.plos.org
Meiotic drivers bias gametogenesis to ensure their transmission into more than half the
offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic drivers destroy the …

The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

NL Nuckolls, AC Mok, JJ Lange, K Yi, TS Kandola… - Elife, 2020 - elifesciences.org
Meiotic drivers are parasitic loci that force their own transmission into greater than half of the
offspring of a heterozygote. Many drivers have been identified, but their molecular …