Direct clonal analysis of tissue and organ maturation in vivo is a critical step in the
interpretation of in vitro cell precursor-progeny relationships. We have developed a method …

The first blood and endothelial cells of amniote embryos appear in close association in the
blood islands of the yolk sac (YS). This association and in vitro lineage analyses have …

Hematopoiesis develops initially as discrete blood islands in the extraembryonic yolk sac of
the embryo. These blood islands consist of clusters of primitive erythrocytes surrounded by …

In the developing embryo, the initial hematopoietic and vascular structure can be identified
as the blood islands of the yolk sac. Blood islands are formed from mesodermal aggregates …

Differentiation of murine embryonic stem cells in suspension culture results in the formation
of cystic embryoid bodies that develop blood islands. In this study pre‐cystic embryoid …

The yolk sac is the first site of hematopoiesis during mammalian development. The yolk sac
is also the first site of blood vessel development. Development of the blood islands in the …

During embryogenesis, haematopoietic and endothelial lineages emerge closely in time
and space. It is thought that the first blood and endothelium derive from a common clonal …

The developmental origin of hematopoietic stem cells has been the subject of much
research. Now that the developmental link between the hematopoietic system and the …

The blood islands of the visceral yolk sac (VYS) are the initial sites of hematopoiesis in
mammals. We have developed a yolk sac explant culture system to study the process of …

In the embryo, the decision to become an endothelial cell (EC) is a bold choice that commits
a cell to the task of generating the blood and lymphatic vascular systems, which form one of …