A new target for gold (I) compounds: glutathione-S-transferase inhibition by auranofin
Nowadays, gold compounds occupy a relevant position constituting a promising class of
experimental anticancer metallodrugs. Several research efforts have been devoted to the …
experimental anticancer metallodrugs. Several research efforts have been devoted to the …
Chemical modification of Auranofin yields a new family of anticancer drug candidates: the gold (I) phosphite analogues
A panel of four novel gold (I) complexes, inspired by the clinically established gold drug
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …
Phosphine-gold (I) compounds as anticancer agents: general description and mechanisms of action
J Carlos Lima, L Rodriguez - Anti-Cancer Agents in Medicinal …, 2011 - ingentaconnect.com
Gold complexes have been explored as metallodrugs with great potential applications as
antitumoral agents. In particular, gold-phosphine derivatives seemed quite promising since …
antitumoral agents. In particular, gold-phosphine derivatives seemed quite promising since …
Molecular mechanisms and proposed targets for selected anticancer gold compounds
Nowadays, gold compounds constitute a family of very promising experimental agents for
cancer treatment. Indeed, several gold (I) and gold (III) compounds were shown to manifest …
cancer treatment. Indeed, several gold (I) and gold (III) compounds were shown to manifest …
Antiproliferative properties of a few auranofin-related gold (I) and silver (I) complexes in leukemia cells and their interferences with the ubiquitin proteasome system
A group of triethylphosphine gold (I) and silver (I) complexes, structurally related to
auranofin, were prepared and investigated as potential anticancer drug candidates. The …
auranofin, were prepared and investigated as potential anticancer drug candidates. The …
On the medicinal chemistry of gold complexes as anticancer drugs
I Ott - Coordination Chemistry Reviews, 2009 - Elsevier
Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …
and platinum compounds are well established in current cancer chemotherapy. However …
Anticancer agents: does a phosphonium behave like a gold (I) phosphine complex? Let a “smart” probe answer!
M Ali, L Dondaine, A Adolle, C Sampaio… - Journal of Medicinal …, 2015 - ACS Publications
Gold phosphine complexes, such as auranofin, have been recognized for decades as
antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or …
antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or …
Mechanisms of cytotoxicity and antitumor activity of gold (I) phosphine complexes: the possible role of mitochondria
MJ McKeage, L Maharaj, SJ Berners-Price - Coordination Chemistry …, 2002 - Elsevier
Well known for their clinical anti-arthritic properties, gold-based drugs have also attracted
interest as potential antitumor agents with gold (I) phosphine derivatives being among the …
interest as potential antitumor agents with gold (I) phosphine derivatives being among the …
Synthesis, chemical characterization, and biological evaluation of a novel auranofin derivative as an anticancer agent
A novel gold (I) complex inspired by the known medicinal inorganic compounds auranofin
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …
Chemistry and biology of three representative gold (III) compounds as prospective anticancer agents
Aubipyc, ie [(bipydmb-H) Au (OH)][PF6](where bipydmb-H= deprotonated 6-(1, 1-
dimethylbenzyl)-2, 2′-bipyridine), Auoxo6, ie [(bipy2Me) 2Au2 (μ-O) 2][PF6] 2 (where …
dimethylbenzyl)-2, 2′-bipyridine), Auoxo6, ie [(bipy2Me) 2Au2 (μ-O) 2][PF6] 2 (where …