Systematic forensic toxicological analysis by GC‐MS in serum using automated mass spectral deconvolution and identification system

M Grapp, HH Maurer, H Desel - Drug testing and analysis, 2016 - Wiley Online Library
Non‐targeted screening of body fluids for psychoactive agents is an essential task for
forensic toxicology. The challenge is the identification of xenobiotics of interest from …

Automated mass spectral deconvolution and identification system for GC-MS screening for drugs, poisons, and metabolites in urine

MR Meyer, FT Peters, HH Maurer - Clinical chemistry, 2010 - academic.oup.com
Background: The challenge in systematic toxicological analysis using gas chromatography
and/or liquid chromatography coupled to mass spectrometry is to identify compounds of …

Fully-automated systematic toxicological analysis of drugs, poisons, and metabolites in whole blood, urine, and plasma by gas chromatography–full scan mass …

A Polettini, A Groppi, C Vignali, M Montagna - Journal of Chromatography B …, 1998 - Elsevier
The availability of automated, rapid and reliable methods for the systematic toxicological
analysis (STA) of drugs and poisons in biosamples is of great importance in clinical and …

[HTML][HTML] Development and validation of a single step GC/MS method for the determination of 41 drugs and drugs of abuse in postmortem blood

A Orfanidis, A Krokos, O Mastrogianni, H Gika… - Forensic Sciences, 2022 - mdpi.com
A toxicology laboratory often receives a high number of samples from cases (autopsies or
clinical) that may require the quick delivery of trustworthy, accurate results. Thus, there is a …

Current state-of-the-art approaches for mass spectrometry in clinical toxicology: an overview

FT Peters, D Wissenbach - Expert Opinion on Drug Metabolism & …, 2023 - Taylor & Francis
Introduction Hyphenated mass spectrometry (MS) has evolved into a very powerful
analytical technique of high sensitivity and specificity. It is used to analyze a very wide …

Forensic screening with GC-MS

HH Maurer - Handbook of Analytical Separations, 2008 - Elsevier
Publisher Summary This chapter describes multi-analyte screening procedures for the
simultaneous detection of several drug classes in blood and urine using gas …

Antidepressants detection and quantification in whole blood samples by GC–MS/MS, for forensic purposes

L Truta, AL Castro, S Tarelho, P Costa… - … of pharmaceutical and …, 2016 - Elsevier
Depression is among the most prevalent psychiatric disorders of our society, leading to an
increase in antidepressant drug consumption that needs to be accurately determined in …

Development of “Quick-DB forensic”: A total workflow from QuEChERS-dSPE method to GC–MS/MS quantification of forensically relevant drugs and pesticides in …

M Kusano, Y Sakamoto, Y Natori, H Miyagawa… - Forensic science …, 2019 - Elsevier
Trends in forensic toxicology show the advancement of rapid and sensitive analytical
methods for qualitative and quantitative analysis of drugs of abuse. However, forensic …

A simple automated procedure for the detection and identification of peaks in gas chromatography-continuous scan mass spectrometry. Application to systematic …

A Polettini - Journal of analytical toxicology, 1996 - academic.oup.com
Gas chromatography-mass spectrometry (GC-MS), which combines the separation power of
GC with the power of MS for the identification of unknown compounds, possesses high …

Derivatization procedures for gas chromatographic–mass spectrometric determination of xenobiotics in biological samples, with special attention to drugs of abuse …

J Segura, R Ventura, C Jurado - Journal of Chromatography B: Biomedical …, 1998 - Elsevier
The development of low cost MS detectors in recent years has promoted an important
increase in the applicability of GC–MS systems to analyze for the presence of foreign …