Comparative activity of two cholecystokinin analogues with partial agonist activity: effects on food intake and brain monoamines

M Orosco, A Gourch, M Rodriguez, J Martinez… - Peptides, 1990 - Elsevier
Two analogues of the C-terminal heptapeptide of cholecystokinin have been synthesized, in
which the C-terminal phenylalanine residue has been replaced by a phenylethylester (JMV …

Pharmacological activity of cholecystokinin analogues modified in the Met28-Gly29 region

C Mendre, M Rodriguez, MF Lignon, MC Galas… - European journal of …, 1990 - Elsevier
Analogues of the C-terminal octapeptide of cholecystokinin (CCK) modified in the Met 28-
Gly 29 region, were tested for their ability to interact with peripheral cholecystokinin …

Effects of a new cholecystokinin analogue (JMV 236) on food intake and brain monoamines in the rat

A Gourch, M Orosco, M Rodriguez, J Martinez… - Neuropeptides, 1990 - Elsevier
JMV 236, a new cholecystokinin-octapeptide-sulfate (CCK 8 S) derivative (Boc-Tyr (SO 3)-
Nle-Gly-Trp-Nle-Asp-Phe-NH 2) has been synthesized in the Centre de Pharmacologie …

Effect of cholecystokinin octapeptide analogues on food intake in the dog

A Inui, M Okita, T Inoue, N Sakatani… - American Journal …, 1989 - journals.physiology.org
Cholecystokinin octapeptide, administered into the third cerebral ventricle (icv), suppresses
feeding in sheep, pigs, chicken, rats, and dogs. Because of the species differences in the …

Cholecystokinin analogs with suppressed central activities

L MaletÍnská, J PÍrková, J Hlaváček, J Slaninová - Peptides, 1998 - Elsevier
Maletínská, L., J. Pírková, J. Hlaváček and J. Slaninová. Cholecystokinin analogs with
suppressed central activities. Peptides 19 (2) 301–308, 1998.—Several analogs of Boc …

Structure-activity relationship studies on cholecystokinin: analogues with partial agonist activity

MC Galas, MF Lignon, M Rodriguez… - American Journal …, 1988 - journals.physiology.org
In the present study, hepta-and octapeptide analogues of the C-terminal part of
cholecystokinin, modified on the C-terminal phenylalanine residue, were synthesized. CCK …

Cholecystokinin-octapeptide fragments: binding to brain cholecystokinin receptors

M Knight, CA Tamminga, L Steardo, ME Beck… - European journal of …, 1984 - Elsevier
Structural determinants of cholecystokinin octapeptide (CCK-8) binding to central nervous
system receptors have been studied to assess the relative importance of the amino and the …

Different peripheral and central antagonistic activity of new glutaramic acid derivatives on satiety induced by cholecystokinin in rats

F Makovec, M Bani, R Chiste, L Revel, LC Rovati… - Regulatory peptides, 1986 - Elsevier
New glutaramic acid derivatives with cholecystokinin antagonistic activity were evaluated for
their capacity to inhibit the satiety effect induced in the rat by intraperitoneal (ip) injection of …

Central cholecystokinin receptors: Opportunity for drug discovery

G Gaviraghi, A Feriani, M Marien, D Trist - Pharmacochemistry Library, 1992 - Elsevier
Cholecystokinin (CCK) is found in high concentrations in the brain, mainly as the C-terminal
octapeptide. CCK meets most of the criteria of a CNS neurotransmitter and has an excitatory …

Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3 …

M Amblard, M Rodriguez, MF Lignon… - Journal of medicinal …, 1993 - ACS Publications
We reported earlier on the synthesis and biological activities of synthetic analogs of
cholecystokinin (CCK) in whichthe C-terminal primary amide group was deleted. Compound …