The histamine sensitization test is a widely used method for measuring the residual toxicity
of pertussis toxin in acellular pertussis vaccines. Although it has been used as a routine …

Because of the exquisite sensitivity of the murine histamine sensitization test (HIST) in
detecting minute amounts of active pertussis toxin (PTx), this animal-based test has been …

Currently, an assay based on fatal sensitization of mice to histamine challenge is widely
used for testing absence of residual pertussis toxin in acellular pertussis containing …

The mouse histamine sensitization test (HIST) is the currently accepted regulatory method
used to monitor residual pertussis toxin (PTx) activity in acellular pertussis vaccines. This …

The histamine sensitisation test (HIST) for pertussis toxin is currently an official batch release
test for acellular pertussis containing combination vaccines in Europe and North America …

Safety requirements stipulate the performance of the in vivo Histamine Sensitization (HS)
test for quality control of acellular pertussis (aP) vaccines. For reasons of reproducibility and …

Regulatory authorities require safety and potency testing prior to the release of each
production lot of acellular pertussis (aP)-containing vaccines. Currently, the murine …

All acellular pertussis (aP) vaccines in use contain chemically inactivated pertussis toxin
(PT). The finding that mice, naturally resistant to the effects of histamine, become sensitive …

Detoxified pertussis toxin (pertussis toxoid) is a major antigen in acellular pertussis
vaccines. Testing these vaccines on the presence of residual pertussis toxin (PTx) and …

Histamine-sensitization test method based on histamine-sensitizing death is widely used for
controlling residual activity of pertussis toxin in acellular pertussis vaccines. The test method …