AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon
cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the …

Using differential display PCR, we identified a novel gene upregulated in renal cell
carcinoma. Characterization of the full-length cDNA and gene revealed that the encoded …

Ion channels play important roles in regulating various cellular processes and malignant
transformation. Expressions of some chloride channels have been suggested to be …

Purpose Cholangiocarcinoma (CCA) is a highly invasive malignant tumor originating from
the bile duct epithelium. Tweety homolog 3 (TTYH3) is a member of the family of calcium …

Tweety family member 3 (TTYH3) is a calcium-activated chloride channel with a non-pore-
forming structure that controls cell volume and signal transduction. We investigated the role …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide, and identification of novel targets is necessary for its diagnosis and treatment …

The expression of TXNDC5, which is induced by hypoxia, stimulates cell proliferation and
angiogenesis. The increased cell proliferation, angiogenesis and hypoxia are main features …

Background TXNDC5 (thioredoxin domain containing 5) is over-expressed in tumors of the
cervix, uterus, stomach and lung. However, not much is known about the functional roles of …

Purpose Observe how specific small RNA interference (siRNA) aimed at TPX2 gene
suppresses TPX2 gene expression in esophageal cancer EC9706 cells and the effect on …

A striking feature of colon tumors is the significant reduction of goblet cells. Although
targeted deletion of Math1 in mice leads to a loss of intestinal secretory cells, including …