Cigarette smoking is the predominant risk factor for bladder cancer. Aromatic amines such
as 4‐aminobiphenyl (ABP) is the major carcinogens found in tobacco smoke. Although it is …

Background: Metabolites of the potent human carcinogen 4-aminobiphenyl (ABP) induce
oxidative stress and form DNA adducts that are associated with hepatic and urinary bladder …

Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder
cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin …

We investigated the mutagenic activation of 2-naphthylamine (2-NA), 3, 2′-dimethyl-4-
aminobiphenyl (DMAB), and 3, 3′-dichlorobenzidine (DCB), bladder carcinogens, by renal …

Renal cell cancer is the main malignant tumour of the kidney and has an increasing
incidence. This type of tumour has a poor prognosis and shows intrinsic resistance to …

In experimental animals such as rats and rabbits, CYP4B1 has an important role in
mutagenic activation of procarcinogens in bladders. In human bladders, it is not clear …

Abstract Cytochrome P450 1A2 (CYP1A2) is hypothesized to catalyze the activation of
arylamines, known human bladder carcinogens present in cigarette smoke. The relationship …

The expression and activity of CYP1A1 were examined in fresh, small-sized lung biopsy
specimens from nine human subjects. CYP1A1 transcripts were detected by reverse …

Exposure to tobacco smoke is an established cause of cancer in humans and cigarette
smoking is a risk factor for urinary bladder cancer development. Aromatic amines are …

Human cytochrome P450 2A13 (CYP2A13) is highly efficient in the metabolic activation of a
tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and …