Functional deficiency of the FEN1 gene has been suggested to cause genomic instability
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …

Abstract Flap endonuclease 1 (FEN1) is a structure-specific nuclease best known for its
critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA …

The underlying molecular mechanisms leading to microsatellite alteration and mutations in
human lung cancer remain unknown. Since Flap endonuclease1 (Fen1), which functions in …

Abstract Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …

Abstract Flap endonuclease 1 (FEN1), a structure-specific endo-and exonuclease, has
multiple functions that determine essential biological processes, such as cell proliferation …

Abstract Flap endonuclease 1 (Fen1) is a key enzyme for maintaining genetic stability in
eukaryotic genomes. Haploinsufficiency of Fen1 leads to the rapid progression of tumours in …

Harnessing genetic differences between cancerous and noncancerous cells offers a
strategy for the development of new therapies. Extrapolating from yeast genetic interaction …

Overexpression of the flap endonuclease FEN1 has been observed in a variety of cancer
types and is a marker for poor prognosis. To better understand the cellular consequences of …

Synthetic lethality strategies for cancer therapy exploit cancer-specific genetic defects to
identify targets that are uniquely essential to the survival of tumor cells. Here we show …

The structure‐specific FEN‐1 endonuclease has been implicated in various cellular
processes, including DNA replication, repair and recombination. In vertebrate cells …